CD4+ chimeric antigen receptor T cells in for the long journey
- Author(s)
- Chen, AXY; Derrick, EB; Beavis, PA; House, IG;
- Details
- Publication Year 2022-05,Volume 100,Issue #5,Page 304-307
- Journal Title
- Immunology & Cell Biology
- Publication Type
- Commentary
- Abstract
- In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long-lived CD4(+) CAR T-cell population with a cytotoxic phenotype.
- Keywords
- CD4-Positive T-Lymphocytes; Humans; Immunotherapy, Adoptive; Receptors, Antigen, T-Cell; *Receptors, Chimeric Antigen/genetics; T-Lymphocytes; chimeric antigen receptor T cells; cytotolytic CD4+ T cells; persistence
- Department(s)
- Laboratory Research
- PubMed ID
- 35307873
- Publisher's Version
- https://doi.org/10.1111/imcb.12545
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-16 03:58:18
Last Modified: 2024-10-16 03:59:23