High Prediagnosis Inflammation-Related Risk Score Associated with Decreased Ovarian Cancer Survival

Brieger, KK; Phung, MT; Mukherjee, B; Bakulski, KM; Anton-Culver, H; Bandera, EV; Bowtell, DDL; Cramer, DW; DeFazio, A; Doherty, JA; Fereday, S; Fortner, RT; Gentry-Maharaj, A; Goode, EL; Goodman, MT; Harris, HR; Matsuo, K; Menon, U; Modugno, F; Moysich, KB; Qin, B; Ramus, SJ; Risch, HA; Rossing, MA; Schildkraut, JM; Trabert, B; Vierkant, RA; Winham, SJ; Wentzensen, N; Wu, AH; Ziogas, A; Khoja, L; Cho, KR; McLean, K; Richardson, J; Grout, B; Chase, A; McKinnon Deurloo, C; Odunsi, K; Nelson, BH; Brenton, JD; Terry, KL; Pharoah, PDP; Berchuck, A; Hanley, GE; Webb, PM; Pike, MC; Pearce, CL; Ovarian Cancer Association Consortium

Author(s): Brieger, KK; Phung, MT; Mukherjee, B; Bakulski, KM; Anton-Culver, H; Bandera, EV; Bowtell, DDL; Cramer, DW; DeFazio, A; Doherty, JA; Fereday, S; Fortner, RT; Gentry-Maharaj, A; Goode, EL; Goodman, MT; Harris, HR; Matsuo, K; Menon, U; Modugno, F; Moysich, KB; Qin, B; Ramus, SJ; Risch, HA; Rossing, MA; Schildkraut, JM; Trabert, B; Vierkant, RA; Winham, SJ; Wentzensen, N; Wu, AH; Ziogas, A; Khoja, L; Cho, KR; McLean, K; Richardson, J; Grout, B; Chase, A; McKinnon Deurloo, C; Odunsi, K; Nelson, BH; Brenton, JD; Terry, KL; Pharoah, PDP; Berchuck, A; Hanley, GE; Webb, PM; Pike, MC; Pearce, CL; Ovarian Cancer Association Consortium;
Details: Publication Year 2022-02,Volume 31,Issue #2,Page 443-452
Journal Title: Cancer Epidemiology, Biomarkers & Prevention
Publication Type: Research article
Abstract: BACKGROUND: There is suggestive evidence that inflammation is related to ovarian cancer survival. However, more research is needed to identify inflammation-related factors that are associated with ovarian cancer survival and to determine their combined effects. METHODS: This analysis used pooled data on 8,147 women with invasive epithelial ovarian cancer from the Ovarian Cancer Association Consortium. The prediagnosis inflammation-related exposures of interest included alcohol use; aspirin use; other nonsteroidal anti-inflammatory drug use; body mass index; environmental tobacco smoke exposure; history of pelvic inflammatory disease, polycystic ovarian syndrome, and endometriosis; menopausal hormone therapy use; physical inactivity; smoking status; and talc use. Using Cox proportional hazards models, the relationship between each exposure and survival was assessed in 50% of the data. A weighted inflammation-related risk score (IRRS) was developed, and its association with survival was assessed using Cox proportional hazards models in the remaining 50% of the data. RESULTS: There was a statistically significant trend of increasing risk of death per quartile of the IRRS [HR = 1.09; 95% confidence interval (CI), 1.03-1.14]. Women in the upper quartile of the IRRS had a 31% higher death rate compared with the lowest quartile (95% CI, 1.11-1.54). CONCLUSIONS: A higher prediagnosis IRRS was associated with an increased mortality risk after an ovarian cancer diagnosis. Further investigation is warranted to evaluate whether postdiagnosis exposures are also associated with survival. IMPACT: Given that pre- and postdiagnosis exposures are often correlated and many are modifiable, our study results can ultimately motivate the development of behavioral recommendations to enhance survival among patients with ovarian cancer.
Keywords: Aged; Carcinoma, Ovarian Epithelial/*mortality; Female; Health Behavior; Humans; Inflammation/*epidemiology; Middle Aged; Ovarian Neoplasms/*mortality; Proportional Hazards Models; Risk Assessment
Department(s): Laboratory Research
PubMed ID: 34789471
Publisher's Version: https://doi.org/10.1158/1055-9965.EPI-21-0977
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-10-11 04:24:41

Last Modified: 2024-10-11 04:26:13