Biomarkers to predict and diagnose pulmonary complications in children post haematopoietic stem cell transplant
- Author(s)
- Walker, H; Haeusler, GM; Cole, T; Neeland, M; Hanna, D; Shanthikumar, S;
- Details
- Publication Year 2024-09,Volume 13,Issue #9,Page e70002
- Journal Title
- Clinical & Translational Immunology
- Publication Type
- Research article
- Abstract
- OBJECTIVES: Haematopoietic cell transplant (HCT) is a cellular therapy for a group of high-risk children with cancer, immunodeficiency and metabolic disorders. Whilst curative for a child's underlying condition, HCT has significant risks associated, including lung injury. These complications are associated with increased post HCT mortality and require improved methods of risk stratification, diagnosis and treatment. METHODS: Biomarkers measured in bronchoalveolar fluid and peripheral blood have been identified for both acute and chronic lung injury post HCT.This review evaluates the current research available investigating the use of these biomarkers to improve clinical care, with a focus on the paediatric cohort. RESULTS: Elevated levels of cytokines such as IL-6, IL-8, G-CSF and TNF were identified as potential predictive biomarkers for the development of post HCT lung disease. The pulmonary microbiome was found to have strong potential as a biomarker pre and post HCT for the development of pulmonary complications. General limitations of the studies identified were study design, retrospective or single centre and not exclusively performed in the paediatric population. CONCLUSION: To translate biomarker discovery into clinical implementation further research is required, utilising larger cohorts of children in prospective trials to validate these biomarkers and determine how they can be translated into better outcomes for children post HCT.
- Publisher
- Wiley
- Keywords
- haematopoietic stem cell transplant; paediatric; pulmonary
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1002/cti2.70002
- Open Access at Publisher's Site
https://doi.org/10.1002/cti2.70002- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-10-01 07:31:01
Last Modified: 2024-10-01 07:37:32