The complexity of immune evasion mechanisms throughout the metastatic cascade
Details
Publication Year 2024-09-16,Volume 25,Issue #10,Page 1793-1808
Journal Title
Nature Immunology
Publication Type
Review
Abstract
Metastasis, the spread of cancer from a primary site to distant organs, is an important challenge in oncology. This Review explores the complexities of immune escape mechanisms used throughout the metastatic cascade to promote tumor cell dissemination and affect organotropism. Specifically, we focus on adaptive plasticity of disseminated epithelial tumor cells to understand how they undergo phenotypic transitions to survive microenvironmental conditions encountered during metastasis. The interaction of tumor cells and their microenvironment is analyzed, highlighting the local and systemic effects that innate and adaptive immune systems have in shaping an immunosuppressive milieu to foster aggressive metastatic tumors. Effectively managing metastatic disease demands a multipronged approach to target the parallel and sequential mechanisms that suppress anti-tumor immunity. This management necessitates a deep understanding of the complex interplay between tumor cells, their microenvironment and immune responses that we provide with this Review.
Publisher
Springer Nature
Department(s)
Laboratory Research
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2024-10-01 03:15:13
Last Modified: 2024-10-01 05:06:17

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