International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Arber, DA; Orazi, A; Hasserjian, RP; Borowitz, MJ; Calvo, KR; Kvasnicka, HM; Wang, SA; Bagg, A; Barbui, T; Branford, S; Bueso-Ramos, CE; Cortes, JE; Dal Cin, P; DiNardo, CD; Dombret, H; Duncavage, EJ; Ebert, BL; Estey, EH; Facchetti, F; Foucar, K; Gangat, N; Gianelli, U; Godley, LA; Gokbuget, N; Gotlib, J; Hellstrom-Lindberg, E; Hobbs, GS; Hoffman, R; Jabbour, EJ; Kiladjian, JJ; Larson, RA; Le Beau, MM; Loh, MLC; Lowenberg, B; Macintyre, E; Malcovati, L; Mullighan, CG; Niemeyer, C; Odenike, OM; Ogawa, S; Orfao, A; Papaemmanuil, E; Passamonti, F; Porkka, K; Pui, CH; Radich, JP; Reiter, A; Rozman, M; Rudelius, M; Savona, MR; Schiffer, CA; Schmitt-Graeff, A; Shimamura, A; Sierra, J; Stock, WA; Stone, RM; Tallman, MS; Thiele, J; Tien, HF; Tzankov, A; Vannucchi, AM; Vyas, P; Wei, AH; Weinberg, OK; Wierzbowska, A; Cazzola, M; Dohner, H; Tefferi, A

Author(s): Arber, DA; Orazi, A; Hasserjian, RP; Borowitz, MJ; Calvo, KR; Kvasnicka, HM; Wang, SA; Bagg, A; Barbui, T; Branford, S; Bueso-Ramos, CE; Cortes, JE; Dal Cin, P; DiNardo, CD; Dombret, H; Duncavage, EJ; Ebert, BL; Estey, EH; Facchetti, F; Foucar, K; Gangat, N; Gianelli, U; Godley, LA; Gokbuget, N; Gotlib, J; Hellstrom-Lindberg, E; Hobbs, GS; Hoffman, R; Jabbour, EJ; Kiladjian, JJ; Larson, RA; Le Beau, MM; Loh, MLC; Lowenberg, B; Macintyre, E; Malcovati, L; Mullighan, CG; Niemeyer, C; Odenike, OM; Ogawa, S; Orfao, A; Papaemmanuil, E; Passamonti, F; Porkka, K; Pui, CH; Radich, JP; Reiter, A; Rozman, M; Rudelius, M; Savona, MR; Schiffer, CA; Schmitt-Graeff, A; Shimamura, A; Sierra, J; Stock, WA; Stone, RM; Tallman, MS; Thiele, J; Tien, HF; Tzankov, A; Vannucchi, AM; Vyas, P; Wei, AH; Weinberg, OK; Wierzbowska, A; Cazzola, M; Dohner, H; Tefferi, A;
Details: Publication Year 2022-09-15,Volume 140,Issue #11,Page 1200-1228
Journal Title: Blood
Publication Type: Guideline
Abstract: The classification of myeloid neoplasms and acute leukemias was last updated in 2016 within a collaboration between the World Health Organization (WHO), the Society for Hematopathology, and the European Association for Haematopathology. This collaboration was primarily based on input from a clinical advisory committees (CACs) composed of pathologists, hematologists, oncologists, geneticists, and bioinformaticians from around the world. The recent advances in our understanding of the biology of hematologic malignancies, the experience with the use of the 2016 WHO classification in clinical practice, and the results of clinical trials have indicated the need for further revising and updating the classification. As a continuation of this CAC-based process, the authors, a group with expertise in the clinical, pathologic, and genetic aspects of these disorders, developed the International Consensus Classification (ICC) of myeloid neoplasms and acute leukemias. Using a multiparameter approach, the main objective of the consensus process was the definition of real disease entities, including the introduction of new entities and refined criteria for existing diagnostic categories, based on accumulated data. The ICC is aimed at facilitating diagnosis and prognostication of these neoplasms, improving treatment of affected patients, and allowing the design of innovative clinical trials.
Keywords: Acute Disease; Consensus; Genomics; *Hematologic Neoplasms/pathology; Humans; *Leukemia/diagnosis/genetics/pathology; *Myeloproliferative Disorders/diagnosis/genetics/pathology; World Health Organization
Department(s): Clinical Haematology
PubMed ID: 35767897
Publisher's Version: https://doi.org/10.1182/blood.2022015850
Terms of Use/Rights Notice: Refer to copyright notice on published article.

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