Clinicopathologic conference: Bloodstream infection in an allogeneic hamatopoietic cell transplant: Thinking beyond the usual
- Author(s)
- Yeoh, K; Lass-Flörl, C; Lamoth, F; Slavin, MA; Williams, E; Neofytos, D;
- Details
- Publication Year 2024-08,Volume 26,Issue #4,Page e14273
- Journal Title
- Transplant Infectious Disease
- Publication Type
- Case report
- Abstract
- This case involves a 53-year-old female with concurrent acute myeloid leukemia (AML) and multiple myeloma. She underwent cytarabine and daunorubicin (7+3) induction chemotherapy followed by cytarabine (HiDAC) consolidation, with an early AML relapse requiring azacitidine and venetoclax therapy. She achieved complete remission and incomplete count recovery. Following fludarabine, melphalan, and thymoglobulin induction chemotherapy, she underwent an allogeneic stem cell transplant with failure to engraft, requiring autologous stem cell rescue, buffy coat, and granulocyte transfusions, eventually presenting with a diffuse skin rash consistent with Steven-Johnson syndrome and toxic epidermal necrolysis, persistent neutropenic fevers and positive blood cultures.
- Publisher
- Wiley
- Keywords
- Humans; Middle Aged; Female; *Leukemia, Myeloid, Acute/therapy/complications; *Multiple Myeloma/therapy; *Hematopoietic Stem Cell Transplantation/adverse effects; Transplantation, Homologous/adverse effects; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Cytarabine/therapeutic use/administration & dosage; Induction Chemotherapy; bloodstream infection; hematopoietic stem cell transplant; immunocompromised
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1111/tid.14273
- Open Access at Publisher's Site
https://doi.org/10.1111/tid.14273- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-09-24 02:22:09
Last Modified: 2024-09-24 02:22:17