Association between tumor-infiltrating lymphocytes and survival in patients with metastatic breast cancer receiving first-line chemotherapy: analysis of CALGB 40502
- Author(s)
- Stover, DG; Salgado, R; Savenkov, O; Ballman, K; Mayer, EL; Magbanua, MJM; Loi, S; Vater, M; Glover, K; Watson, M; Wen, Y; Symmans, WF; Perou, C; Carey, LA; Partridge, AH; Rugo, HS;
- Details
- Publication Year 2024-08-21,Volume 10,Issue #1,Page 75
- Journal Title
- NPJ Breast Cancer
- Publication Type
- Research article
- Abstract
- Association of stromal tumor-infiltrating lymphocytes (sTILs) with survival outcomes among patients with metastatic breast cancer (MBC) remains unclear. The primary objective was to evaluate the association of sTILs with progression-free survival in randomized phase III trial CALGB 40502. sTILs were associated with progression-free and overall survival in chemotherapy-treated MBC when controlling for treatment arm; however, this effect did not remain significant after additional adjustment for hormone receptor status. CALGB is now part of the Alliance for Clinical Trials in Oncology. Trial Registration: ClinicalTrials.gov: NCT00785291.
- Publisher
- Springer Nature
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1038/s41523-024-00683-x
- Open Access at Publisher's Site
https://doi.org/10.1038/s41523-024-00683-x- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-09-24 02:20:11
Last Modified: 2024-09-24 02:22:35