18F-DCFPyL PSMA PET/CT Tracheobronchial Uptake in Patients with Prostate Cancer: Incidence and Etiology

Osman, MM; Iravani, A; Mitchell, C; Hicks, RJ; Perry, E; Hofman, MS

Author(s): Osman, MM; Iravani, A; Mitchell, C; Hicks, RJ; Perry, E; Hofman, MS;
Details: Publication Year 2024-09-03,Volume 65,Issue #9,Page 1383-1386
Journal Title: Journal of Nuclear Medicine
Publication Type: Research article
Abstract: We evaluated the incidence and potential etiology of tracheobronchial uptake in patients being evaluated by (18)F-DCFPyL PET/CT for prostate cancer (PCa). Methods: The study included a consecutive 100 PCa patients referred for (18)F-DCFPyL PET/CT. The PET/CT scans were retrospectively reviewed. The presence or absence of physiologic tracheobronchial uptake on PET/CT was recorded. To further evaluate tracheal prostate-specific membrane antigen (PSMA) expression, immunohistochemistry was performed on tracheal samples taken from 2 men who had surgical resection of lung cancer. Results: Tracheal uptake was present in 31 of 100 patients (31%). When tracheal uptake was present, the SUV(max) was significantly higher in the left main bronchus (mean, 2.7) than in the right (mean, 2.3) (P < 0.001). Histopathologic testing of tracheobronchial samples showed PSMA expression in bronchial submucosal glands. Conclusion: In PCa patients undergoing (18)F-DCFPyL PET/CT, tracheobronchial uptake occurred in 31% of patients. This is attributed to normal physiologic PSMA expression in bronchial submucosal glands.
Publisher: Society of Nuclear Medicine and Molecular Imaging
Keywords: Humans; Male; *Positron Emission Tomography Computed Tomography; *Prostatic Neoplasms/diagnostic imaging/metabolism; *Trachea/diagnostic imaging/metabolism; Aged; *Glutamate Carboxypeptidase II/metabolism; *Bronchi/diagnostic imaging/metabolism; Middle Aged; *Lysine/analogs & derivatives/metabolism; Retrospective Studies; *Urea/analogs & derivatives/metabolism; Antigens, Surface/metabolism; Aged, 80 and over; Biological Transport; Radiopharmaceuticals; 18F-DCFPyL; Pet/ct; prostate cancer; submucosal glands; trachea
Department(s): Pathology; Cancer Imaging
Publisher's Version: https://doi.org/10.2967/jnumed.124.267772
Open Access at Publisher's Site: https://doi.org/10.2967/jnumed.124.267772
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-09-19 02:59:44

Last Modified: 2024-09-19 03:00:01