Primary gastric diffuse large B-cell lymphoma: A multicentre retrospective study
- Author(s)
- Lewis, CS; Joy, G; Jensen, P; Barraclough, A; Franco, N; Talaulikar, D; Hawkes, EA; El-Galaly, TC; Villa, D; Dickinson, M; Seymour, JF; Cheah, CY;
- Details
- Publication Year 2024-08,Volume 205,Issue #2,Page 534-541
- Journal Title
- British Journal of Haematology
- Publication Type
- Research article
- Abstract
- Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) accounts for the majority of extra-nodal DLBCL. Even so, literature is lacking on early, localised presentations. We studied a cohort of patients with stage I disease, diagnosed between 2006 and 2018, from six centres between Australia, Canada and Denmark. Our goal was to characterise outcomes, review treatment and investigate the role of interim positron emission tomography (iPET). Thirty-seven eligible patients were identified. The median duration of follow-up was 42.2 months. All received chemoimmunotherapy with 91.9% (n = 34) given rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP). 35.1% (n = 13) underwent consolidative radiotherapy. Eighteen patients were H. pylori positive and 11 had the documentation of H. pylori eradication therapy. The 4-year progression-free survival and overall survival of R-CHOP was 88% (95% CI: 71-95) and 91% (95% CI: 75-97) respectively. All patients who achieved a partial metabolic response or complete metabolic response on iPET went on to achieve complete response at the end of treatment. R-CHOP-based therapy with iPET assessment appears to offer favourable outcomes, with radiotherapy and H. pylori eradication therapy implemented on a case-by-case basis.
- Publisher
- Wiley
- Keywords
- Humans; *Lymphoma, Large B-Cell, Diffuse/mortality/therapy; Male; Female; Middle Aged; Aged; Retrospective Studies; *Antineoplastic Combined Chemotherapy Protocols/therapeutic use; *Stomach Neoplasms/therapy/pathology; Adult; Aged, 80 and over; Rituximab/therapeutic use/administration & dosage; Vincristine/therapeutic use/administration & dosage; Prednisone/therapeutic use/administration & dosage; Cyclophosphamide/therapeutic use/administration & dosage; Doxorubicin/therapeutic use/administration & dosage; Helicobacter Infections/complications/drug therapy; Helicobacter pylori; Positron-Emission Tomography; Lymphoma, Non-Hodgkin; Dlbcl; extranodal lymphoma; gastric DLBCL; gastric lymphoma
- Department(s)
- Clinical Haematology
- Publisher's Version
- https://doi.org/10.1111/bjh.19470
- Open Access at Publisher's Site
https://doi.org/10.1111/bjh.19470- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-09-19 02:59:41
Last Modified: 2024-09-19 03:00:01