Single gene mutations and prognosis in limited-stage follicular lymphoma treated with radiation therapy
- Author(s)
- Hershenfeld, SA; Tobin, JWD; Shelton, V; Calvente, L; Lajkosz, K; Liu, T; Brodtkorb, M; d'Amore, FA; Ludvigsen, M; Baetz, T; LeBrun, D; Johnson, N; Crump, M; Hong, M; Kuruvilla, J; Tremblay-LeMay, R; MacManus, M; Tsang, R; Hodgson, DC; Gandhi, MK; Kridel, R;
- Journal Title
- British Journal of Haematology
- Publication Type
- Online publication before print
- Abstract
- Radiotherapy is routinely used for management of limited-stage follicular lymphoma (FL), yet half of patients ultimately relapse. We hypothesized that the presence of specific gene mutations may predict outcomes. We performed targeted sequencing of a 69-gene panel in 117 limited-stage FL patients treated with radiotherapy and identified recurrently mutated genes. CREBBP was most frequently mutated, and mutated CREBBP was associated with inferior progression-free survival, though not after false discovery rate adjustment. This association failed to validate in an independent cohort. We conclude that recurrent gene mutations do not predict outcomes in this setting. Alternative biomarkers may offer better prognostic insight.
- Keywords
- genetics; non‐Hodgkin lymphoma; prognostic factors; radiotherapy
- Department(s)
- Radiation Oncology
- Publisher's Version
- https://doi.org/10.1111/bjh.19698
- Open Access at Publisher's Site
https://doi.org/10.1111/bjh.19698- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-09-12 06:44:24
Last Modified: 2024-09-12 06:49:54