Bispecific antibodies: advancing precision oncology
Journal Title
Trends in Cancer
Publication Type
Online publication before print
Abstract
Bispecific antibodies (bsAbs) are engineered molecules designed to target two different epitopes or antigens. The mechanism of action is determined by the bsAb molecular targets and structure (or format), which can be manipulated to create variable and novel functionalities, including linking immune cells with tumor cells, or dual signaling pathway blockade. Several bsAbs have already changed the treatment landscape of hematological malignancies and select solid cancers. However, the mechanisms of resistance to these agents are understudied and the management of toxicities remains challenging. Herein, we review the principles in bsAb engineering, current understanding of mechanisms of action and resistance, data for clinical application, and provide a perspective on ongoing challenges and future developments in this field.
Keywords
T cell engagers; antibody engineering; bispecific antibodies; dual-targeted therapy; immunotherapy
Department(s)
Medical Oncology; Laboratory Research
Open Access at Publisher's Site
https://doi.org/10.1016/j.trecan.2024.07.002
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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