The Therapeutic Potential of Cannabidiol in Revolutionising Opioid Use Disorder Management

Le, K; Au, J; Hua, J; Le, KDR

Author(s): Le, K; Au, J; Hua, J; Le, KDR;
Details: Publication Year 2023-12,Volume 15,Issue #12,Page e50634
Journal Title: Cureus
Publication Type: Review
Abstract: Opioid use disorder (OUD) is a significant cause of morbidity and mortality worldwide and is linked to a complex interplay of biopsychosocial factors as well as the increasing overprescription and availability of opioid medications. Current OUD management relies on the controlled provision of opioid medications, such as methadone or buprenorphine, known as opioid replacement therapy. There is variable evidence regarding the long-term efficacy of these medications in improving the management of OUD, thereby necessitating an exploration into innovative approaches to complement, or even take the place of, existing treatment paradigms. Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has garnered attention for its diverse pharmacological properties, including anti-inflammatory, analgesic, and anxiolytic effects. Preliminary studies suggest that CBD may target opioid withdrawal pathways that make CBD a potential therapeutic option for OUD. This narrative review synthesises current literature surrounding OUD and offers a nuanced review of the current and future role of CBD in managing this condition. In doing so, we highlight the potential avenues to explore with respect to CBD research for the guidance and development of further research opportunities, framework and policy development, and clinical considerations before medicinal CBD can be integrated into evidence-based clinical guidelines.
Keywords: cannabidiol; cannabinoids; medical marijuana; opioid replacement therapy; opioid use disorder; opioids
Department(s): Surgical Oncology
PubMed ID: 38226097
Publisher's Version: https://doi.org/10.7759/cureus.50634
Open Access at Publisher's Site: https://doi.org/10.7759/cureus.50634
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-08-20 06:08:33

Last Modified: 2024-08-20 06:56:56