Volatile and Intravenous Anesthetics and Cancer
Journal Title
In: Hagberg, C.A., Gottumukkala, V.N.R., Riedel, B.J., Nates, J.L., Buggy, D.J. (eds) Perioperative Care of the Cancer Patient
Publication Type
Book section
Abstract
Surgical resection remains a key treatment option for patients with solid tumors and requires the administration of anesthesia. The perioperative surgical response has been implicated in the progression of malignant disease. The role of anesthetic agents in modulation of this perioperative stress response and long-term cancer outcomes is increasingly being considered. This chapter details the current available preclinical and clinical evidence implicating general anesthetic agents in the modulation of cancer biology and long-term cancer outcomes. While the data support plausibility for the implication for general anesthesia in modulation of cancer progression, prospective clinical trials are still ongoing, and robust evidence on which to base a change in clinical practice of anesthesia for cancer surgery is still pending. With more than 17 million patients expected to need surgery (and anesthesia) for resection of cancer in 2030, there is a critical need to better understand the implications of anesthesia on this patient population.
Publisher
Elsevier
Keywords
Anesthesia; cancer; perioperative outcomes; propofol; volatile
Department(s)
Anaesthetics
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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