Human papillomavirus associated oropharyngeal cancer now the most common mucosal head and neck cancer in Queensland
- Author(s)
- Porceddu, SV; Negrello, T; Rawson, N; Dunn, N; Batstone, M; Collins, M; Dowthwaite, S; Hughes, BG; Kenny, L; Ladwa, R; Panizza, B; Cossio, D;
- Journal Title
- Journal of Medical Imaging and Radiation Oncology
- Publication Type
- Research article
- Abstract
- INTRODUCTION: The profile and outcomes of head and neck cancer throughout Australia has changed over the past decade. The aim of this study was to perform a population-based analysis of incidence, demographics, stage, treatments and outcomes of patients diagnosed with oropharyngeal squamous cell carcinoma (OPSCC), with a particular focus on HPV-associated disease. METHODS: This was a retrospective analysis of prospectively collected data within the Queensland Oncology Repository (QOR) and analysed by the Queensland Cancer Control Analysis Team. The cohort included patients diagnosed in Queensland between 1 January 2015 and 31 December 2019. Outcome measures included incidence of new OPSCC cases, age-standardised rates (ASR) (3-year average), demographics, p16 status, stage (8th Edition American Joint Commission on Cancer), treatments, and 2- and 5-year overall survival. RESULTS: There were 1527 newly diagnosed OPSCC, representing 96% (1527/1584) of all oropharyngeal cancers. It was the most common head and neck cancer diagnosed, with oral cavity cancer being the second most common (n = 1171). Seventy-seven percent were p16 positive (1170/1527), of which 87% (1019/1170) were male. The median age was 61 years and 49% (568/1170) presented with Stage I disease. The ASR was 6.3/100,000, representing a 144% incidence increase since 1982 (2.6/100,000). Radiotherapy was utilised in 91% of p16+ cases with 2- and 5- year overall survival of 89% and 79%, respectively. CONCLUSION: OPSCC is now the most common mucosal head and neck cancer diagnosed in Queensland, having surpassed oral cavity cancer. The majority are HPV-associated (p16+), presenting with early-stage disease with a favourable prognosis.
- Publisher
- Wiley
- Keywords
- head and neck cancer; human papillomavirus; oropharyngeal; radiotherapy; squamous cell carcinoma
- Department(s)
- Radiation Oncology
- Publisher's Version
- https://doi.org/10.1111/1754-9485.13643
- Open Access at Publisher's Site
https://doi.org/10.1111/1754-9485.13643- Terms of Use/Rights Notice
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Creation Date: 2024-07-17 04:32:37
Last Modified: 2024-07-17 04:35:46