The paradox of platypnoea-orthodeoxia syndrome
- Author(s)
- Leaver, BA; Cliff, ERS; Jefford, M; Fogarty, S; Zentner, D;
- Details
- Publication Year 2024-04,Volume 54,Issue #4,Page 675-677
- Journal Title
- Internal Medicine Journal
- Publication Type
- Case report
- Abstract
- Platypnoea-orthodeoxia is a rare clinical syndrome characterised by dyspnoea and oxygen desaturation in the upright position which improves when supine. It requires two components: a sufficiently sized anatomical vascular defect (typically intra-cardiac or intra-pulmonary) combined with a functional component that promotes positional right-to-left shunting. We describe the rare occurrence of a patient with platypnoea-orthodeoxia syndrome (POS) because of a paradoxical shunt through a patent foramen ovale caused by a large right atrial line-associated thrombus in a male with metastatic oesophageal cancer undergoing chemotherapy. This case is a timely reminder to consider POS amongst differentials for hypoxia as it is often treatable if recognised.
- Publisher
- Wiley
- Keywords
- Humans; Male; *Platypnea Orthodeoxia Syndrome; *Foramen Ovale, Patent/diagnosis/diagnostic imaging; Dyspnea/etiology/complications; Hypoxia/diagnosis/etiology; cardiac thrombus; line‐associated thrombus; platypnoea–orthodeoxia; shunt
- Department(s)
- Medical Oncology
- Publisher's Version
- https://doi.org/10.1111/imj.16365
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-07-11 06:58:38
Last Modified: 2024-07-11 07:07:57