Emerging Theranostics for Prostate Cancer and a Model of Prostate-specific Membrane Antigen Therapy
- Author(s)
- Jewell, K; Hofman, MS; Ong, JSL; Levy, S;
- Details
- Publication Year 2024-04,Volume 311,Issue #1,Page e231703
- Journal Title
- Radiology
- Publication Type
- Review
- Abstract
- There is increasing demand worldwide to develop diagnostic and therapeutic (theranostic) markers for prostate cancer. One target of interest is prostate-specific membrane antigen (PSMA), a protein which is overexpressed in prostate cancer cells. Over the past decade, a growing body of literature has demonstrated that radiolabeled ligands that target PSMA show favorable clinical response and survival outcomes in patients with advanced prostate cancer. This focused review provides background to the development of PSMA as a target, an overview of key studies informing our current approach to radioligand-based imaging and therapy for prostate cancer, and a model for real-world implementation of PSMA theranostics based on an Australian experience.
- Publisher
- Radiological Society of North America
- Keywords
- Male; Humans; *Precision Medicine; Prostate; Australia; *Prostatic Neoplasms/diagnostic imaging/therapy; Pelvis
- Department(s)
- Cancer Imaging
- Publisher's Version
- https://doi.org/10.1148/radiol.231703
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-07-11 01:39:07
Last Modified: 2024-07-11 01:47:52