Invasive fungal disease in children with solid tumors: An Australian multicenter 10-year review
- Author(s)
- Jain, N; Ryan, AL; Haeusler, GM; McMullan, BJ; Moore, AS; Bartlett, AW; Blyth, CC; Kotecha, RS; Yeoh, DK; Clark, JE;
- Details
- Publication Year 2024-07,Volume 71,Issue #7,Page e31031
- Journal Title
- Pediatric Blood & Cancer
- Publication Type
- Research article
- Abstract
- Invasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004-2013) were analyzed to document prevalence, clinical characteristics, and microbiology of IFD. Amongst 2067 children treated for solid malignancy, IFD prevalence was 1.9% overall and 1.4% for proven/probable IFD. Of all IFD episodes, 42.5% occurred in patients with neuroblastoma (prevalence 7.0%). Candida species comprised 54.8% of implicated pathogens in proven/probable IFD. In children with solid tumors, IFD is rare, and predominantly caused by yeasts.Routine prophylaxis may not be warranted.
- Publisher
- Wiley
- Keywords
- Humans; Child; Male; Female; *Neoplasms/microbiology/epidemiology; Retrospective Studies; Child, Preschool; Australia/epidemiology; Infant; Adolescent; *Invasive Fungal Infections/epidemiology/etiology/prevention & control; Prevalence; Infant, Newborn; cancer; children; invasive fungal disease; prophylaxis; solid tumors
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1002/pbc.31031
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-07-11 01:39:06
Last Modified: 2024-07-11 01:47:52