Utility of Repeat Sampling in Bilateral Aldosterone Suppression During Adrenal Vein Sampling for Primary Aldosteronism

Author(s): Halim, B; Yong, EXZ; Egan, M; MacIsaac, RJ; O'Neal, D; Sachithanandan, N;
Details: Publication Year 2024,Volume 2,Issue #4,Page 1-6
Journal Title: JCEM Case Reports
Publication Type: Case report
Abstract: Primary aldosteronism (PA) is the most common form of secondary hypertension. Accurate subtyping of PA is essential to identify unilateral disease, as adrenalectomy improves outcomes. Subtyping PA requires adrenal vein sampling (AVS), which is technically challenging and results from AVS may not always be conclusive. We present a case of a 37-year-old man with PA whose AVS studies were inconclusive due to apparent bilateral aldosterone suppression (ABAS). As a result, our patient was misdiagnosed as having bilateral PA and medically managed until a repeat AVS showed lateralization to the right adrenal gland. ABAS is an underrecognized phenomenon that may confound the subtyping of PA. We recommend repeating AVS in such cases and discuss strategies to minimize ABAS.
Publisher: Oxford University Press
Department(s): Cancer Imaging
Publisher's Version: https://doi.org/10.1210/jcemcr/luae051
Open Access at Publisher's Site: https://doi.org/10.1210/jcemcr/luae051
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-07-09 08:01:41

Last Modified: 2024-07-09 08:03:53