Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency
- Author(s)
- Chan, S; Morgan, B; Yong, MK; Margetts, M; Farchione, AJ; Lucas, EC; Godsell, J; Giang, NA; Slade, CA; von Borstel, A; Bryant, VL; Howson, LJ;
- Details
- Publication Year 2024-05-20,Volume 15,Issue #1,Page 4286
- Journal Title
- Nature Communications
- Publication Type
- Research article
- Abstract
- The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susceptibility to infections. γδ T cells are a subset of unconventional T cells that play crucial roles in host defence against infections. In this study, we aim to determine the roles and functions of γδ T cells in CVID. We observe a higher frequency of Vδ1(+) γδ T cells compared to healthy controls, particularly in older patients. We also find a higher proportion of effector-memory Vδ1(+) γδ T cells and a more clonal T cell receptor (TCR) repertoire in CVID. The most significant driver of the Vδ1(+) γδ T cell expansion and phenotype in CVID patients is persistent cytomegalovirus (CMV) viremia. These findings provide valuable insights into γδ T cell biology and their contribution to immune defence in CVID.
- Publisher
- Springer Nature
- Keywords
- Humans; *Common Variable Immunodeficiency/immunology/virology; *Receptors, Antigen, T-Cell, gamma-delta/metabolism/immunology; Male; Female; *Cytomegalovirus Infections/immunology/virology; Adult; *Cytomegalovirus/immunology; Middle Aged; Aged; Young Adult; T-Lymphocyte Subsets/immunology; Viremia/immunology; Adolescent; Case-Control Studies
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1038/s41467-024-48527-3
- Open Access at Publisher's Site
https://doi.org/10.1038/s41467-024-48527-3- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-07-04 12:35:18
Last Modified: 2024-07-04 12:38:43