Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency
Details
Publication Year 2024-05-20,Volume 15,Issue #1,Page 4286
Journal Title
Nature Communications
Publication Type
Research article
Abstract
The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susceptibility to infections. γδ T cells are a subset of unconventional T cells that play crucial roles in host defence against infections. In this study, we aim to determine the roles and functions of γδ T cells in CVID. We observe a higher frequency of Vδ1(+) γδ T cells compared to healthy controls, particularly in older patients. We also find a higher proportion of effector-memory Vδ1(+) γδ T cells and a more clonal T cell receptor (TCR) repertoire in CVID. The most significant driver of the Vδ1(+) γδ T cell expansion and phenotype in CVID patients is persistent cytomegalovirus (CMV) viremia. These findings provide valuable insights into γδ T cell biology and their contribution to immune defence in CVID.
Publisher
Springer Nature
Keywords
Humans; *Common Variable Immunodeficiency/immunology/virology; *Receptors, Antigen, T-Cell, gamma-delta/metabolism/immunology; Male; Female; *Cytomegalovirus Infections/immunology/virology; Adult; *Cytomegalovirus/immunology; Middle Aged; Aged; Young Adult; T-Lymphocyte Subsets/immunology; Viremia/immunology; Adolescent; Case-Control Studies
Department(s)
Infectious Diseases
Open Access at Publisher's Site
https://doi.org/10.1038/s41467-024-48527-3
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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