Survival outcomes in patients with acute myeloid leukaemia who received subsequent therapy for relapse in QUAZAR AML-001
- Author(s)
- Ravandi, F; Döhner, H; Wei, AH; Montesinos, P; Pfeilstöcker, M; Papayannidis, C; Lai, Y; Wang, K; See, WL; de Menezes, DL; Petrlik, E; Prebet, T; Roboz, GJ;
- Details
- Publication Year 2024-03,Volume 204,Issue #3,Page 877-886
- Journal Title
- British Journal of Haematology
- Publication Type
- Research article
- Abstract
- In the phase 3 QUAZAR AML-001 trial (NCT01757535) of patients with acute myeloid leukaemia (AML) in remission following intensive chemotherapy (IC) and ineligible for haematopoietic stem cell transplant (HSCT), oral azacitidine (Oral-AZA) maintenance significantly prolonged overall survival (OS) versus placebo. The impact of subsequent treatment following maintenance has not been evaluated. In this post hoc analysis, OS was estimated for patients who received subsequent AML therapy, and by regimen received (IC or lower-intensity therapy). First subsequent therapy (FST) was administered after treatment discontinuation in 134/238 Oral-AZA and 173/234 placebo patients. OS from randomization in patients who received FST after Oral-AZA versus placebo was 17.8 versus 12.9 months (HR: 0.82 [95% CI: 0.64-1.04], median follow-up: 56.7 months); OS from FST was similar between arms. Among patients who received injectable hypomethylating agents as FST, median OS was 8.2 versus 4.9 months in the Oral-AZA versus placebo groups (HR: 0.66 [95% CI: 0.41-1.06]). Forty-eight patients (16/238 Oral-AZA, 32/234 placebo) received HSCT following treatment discontinuation, including six Oral-AZA patients still in first remission; Oral-AZA OS benefit persisted when censoring these patients. Oral-AZA maintenance can prolong AML remission duration without negatively impacting survival outcomes after salvage therapies.
- Publisher
- Wiley
- Keywords
- Humans; *Azacitidine/therapeutic use; Antimetabolites, Antineoplastic/therapeutic use; Neoplasm Recurrence, Local/drug therapy; *Leukemia, Myeloid, Acute/drug therapy; Remission Induction; Chronic Disease; Antimetabolites/therapeutic use; acute myeloid leukaemia; haematopoietic stem cell transplant; maintenance treatment; oral azacitidine; subsequent treatment
- Department(s)
- Clinical Haematology
- Publisher's Version
- https://doi.org/10.1111/bjh.19202
- Open Access at Publisher's Site
https://doi.org/10.1111/bjh.19202- Terms of Use/Rights Notice
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Creation Date: 2024-04-18 05:09:38
Last Modified: 2024-04-18 05:09:48