Embracing cancer complexity: Hallmarks of systemic disease
- Author(s)
- Swanton, C; Bernard, E; Abbosh, C; André, F; Auwerx, J; Balmain, A; Bar-Sagi, D; Bernards, R; Bullman, S; DeGregori, J; Elliott, C; Erez, A; Evan, G; Febbraio, MA; Hidalgo, A; Jamal-Hanjani, M; Joyce, JA; Kaiser, M; Lamia, K; Locasale, JW; Loi, S; Malanchi, I; Merad, M; Musgrave, K; Patel, KJ; Quezada, S; Wargo, JA; Weeraratna, A; White, E; Winkler, F; Wood, JN; Vousden, KH; Hanahan, D;
- Details
- Publication Year 2024-03-28,Volume 187,Issue #7,Page 1589-1616
- Journal Title
- Cell
- Publication Type
- Review
- Abstract
- The last 50 years have witnessed extraordinary developments in understanding mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical framework, our understanding of the molecular basis of systemic manifestations and the underlying causes of cancer-related death remains incomplete. Looking forward, elucidating how tumors interact with distant organs and how multifaceted environmental and physiological parameters impinge on tumors and their hosts will be crucial for advances in preventing and more effectively treating human cancers. In this perspective, we discuss complexities of cancer as a systemic disease, including tumor initiation and promotion, tumor micro- and immune macro-environments, aging, metabolism and obesity, cancer cachexia, circadian rhythms, nervous system interactions, tumor-related thrombosis, and the microbiome. Model systems incorporating human genetic variation will be essential to decipher the mechanistic basis of these phenomena and unravel gene-environment interactions, providing a modern synthesis of molecular oncology that is primed to prevent cancers and improve patient quality of life and cancer outcomes.
- Publisher
- Cell Press
- Keywords
- Humans; Quality of Life; *Neoplasms/genetics/pathology; Carcinogenesis; Obesity/complications; *Microbiota
- Department(s)
- Medical Oncology; Laboratory Research
- Publisher's Version
- https://doi.org/10.1016/j.cell.2024.02.009
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-04-18 04:53:28
Last Modified: 2024-04-18 05:10:25