Recent developments in the diagnosis and management of N1 penile cancer
Journal Title
Current Opinion in Urology
Publication Type
Review
Abstract
PURPOSE OF REVIEW: This article presents a critical review of the current literature to provide a brief update on the contemporary advances in diagnosing and managing N1 penile cancer. RECENT FINDINGS: Penile squamous cell carcinoma (pSCC) has evolved from being an orphan field for cancer innovation. Advances in the understanding tumour biology have enabled sophisticated diagnostics and predictive modelling to better characterize inguinal disease. Minimally invasive inguinal lymph node dissection is emerging as a technique that reduces morbidity while maintaining oncological safety. Furthermore, robust clinical trials are underway ,which will provide level one evidence to guide treatment decisions. Exciting advances in the field of immune-oncology offer promise as adjuvant therapies. International collaboration and centralisation of care will be essential to driving translational research and equitable evidence-based care. SUMMARY: Improving outcomes for men with pSCC remains a global challenge. Radical inguinal lymph node dissection remains the gold standard for diagnosing and curing N1 disease. Although many promising developments are on the horizon, high-level evidence is required to guide therapy.
Publisher
Wolters Kluwer
Keywords
Male; Humans; *Penile Neoplasms/diagnosis/surgery; Lymph Node Excision; *Carcinoma, Squamous Cell/diagnosis/therapy; Medical Oncology; Combined Modality Therapy
Department(s)
Surgical Oncology
PubMed ID
36444651
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-06-13 07:55:07
Last Modified: 2023-06-13 07:56:08

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