Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022
- Author(s)
- Baumgartner, F; Baer, C; Bamopoulos, S; Ayoub, E; Truger, M; Meggendorfer, M; Lenk, M; Hoermann, G; Hutter, S; Müller, H; Walter, W; Müller, ML; Nadarajah, N; Blombery, P; Keller, U; Kern, W; Haferlach, C; Haferlach, T;
- Details
- Publication Year 2024-03-21,Volume 143,Issue #12,Page 1139-1156
- Journal Title
- Blood
- Publication Type
- Research article
- Abstract
- The World Health Organization (WHO) classification of hematolymphoid tumors and the International Consensus Classification (ICC) of 2022 introduced major changes to the definition of chronic myelomonocytic leukemia (CMML). To assess its qualitative and quantitative implications for patient care, we started with 3311 established CMML cases (according to WHO 2017 criteria) and included 2130 oligomonocytosis cases fulfilling the new CMML diagnostic criteria. Applying both 2022 classification systems, 356 and 241 of oligomonocytosis cases were newly classified as myelodysplastic (MD)-CMML (WHO and ICC 2022, respectively), most of which were diagnosed as myelodysplastic syndrome (MDS) according to the WHO 2017 classification. Importantly, 1.5 times more oligomonocytosis cases were classified as CMML according to WHO 2022 than based on ICC, because of different diagnostic criteria. Genetic analyses of the newly classified CMML cases showed a distinct mutational profile with strong enrichment of MDS-typical alterations, resulting in a transcriptional subgroup separated from established MD and myeloproliferative CMML. Despite a different cytogenetic, molecular, immunophenotypic, and transcriptional landscape, no differences in overall survival were found between newly classified and established MD-CMML cases. To the best of our knowledge, this study represents the most comprehensive analysis of routine CMML cases to date, both in terms of clinical characterization and transcriptomic analysis, placing newly classified CMML cases on a disease continuum between MDS and previously established CMML.
- Publisher
- American Society of Hematology
- Keywords
- Humans; Consensus; *Myelodysplastic Syndromes/diagnosis/genetics; *Leukemia, Myelomonocytic, Chronic/diagnosis/genetics/pathology; Leukocytosis; World Health Organization; Prognosis; Organic Chemicals
- Department(s)
- Pathology
- Publisher's Version
- https://doi.org/10.1182/blood.2023021199
- Open Access at Publisher's Site
https://doi.org/10.1182/blood.2023021199- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-03-28 06:48:07
Last Modified: 2024-03-28 06:51:46