Heart of the matter-infection and xenotransplantation
- Author(s)
- Saharia, KK; University of Maryland Xenotransplant Team; Hall, VG; Chesdachai, S; Porrett, P; Fishman, JA; Pouch, SM;
- Details
- Publication Year 2024-02,Volume 26,Issue #1,Page e14206
- Journal Title
- Transplant Infectious Disease
- Publication Type
- Case report
- Abstract
- In this clinicopathological conference, invited experts discussed a previously published case of a patient with nonischemic cardiomyopathy who underwent heart transplantation from a genetically modified pig source animal. His complex course included detection of porcine cytomegalovirus by plasma microbial cell-free DNA and eventual xenograft failure. The objectives of the session included discussion of selection of immunosuppressive regimens and prophylactic antimicrobials for human xenograft recipients, description of infectious disease risk assessment and mitigation in potential xenograft donors and understanding of screening and therapeutic strategies for potential xenograft-related infections.
- Publisher
- Wiley
- Keywords
- Animals; Humans; Swine; Transplantation, Heterologous/adverse effects; *Heart Transplantation/adverse effects; Immunosuppressive Agents/adverse effects; Tissue Donors; heart transplant; infection; prophylaxis; transmission; xenotransplant
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1111/tid.14206
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-03-26 02:54:46
Last Modified: 2024-03-26 02:55:34