Low-risk penicillin allergy delabeling: a scoping review of direct oral challenge practice, implementation, and multi-disciplinary approaches
- Author(s)
- Mitri, E; Reynolds, G; Hornung, CJ; Trubiano, JA;
- Journal Title
- Expert Review of Anti-Infective Therapy
- Publication Type
- Review
- Abstract
- INTRODUCTION: Penicillin allergy is common, and there is increased clinician interest in direct oral challenge (DOC) as a testing strategy for low-risk penicillin allergy. To aid wider implementation of DOC, consensus definitions of low-risk penicillin allergy phenotypes, and standardized approaches to assessment, DOC procedures, and evaluation, are required. AREAS COVERED: This review systematically reviews studies that have utilized penicillin DOC in healthcare settings to identify heterogeneity in implementation approaches and synthesize low-risk definitions, procedures, and evaluation. EXPERT OPINION: Opportunity exists to standardize penicillin DOC procedures in patients with a low-risk penicillin allergy to optimize antimicrobial prescribing and reduce the burden of penicillin allergy. Standardizing the definitions of 'low-risk' and 'positive challenge,' and improving the evaluation of patient safety, alongside the development of a unified approach to the structure of undertaking an oral challenge, is likely to increase uptake and confidence among non-allergist clinicians.
- Publisher
- Taylor & Francis
- Keywords
- Humans; Anti-Bacterial Agents/adverse effects; Skin Tests/methods; Penicillins/adverse effects; *Drug Hypersensitivity/diagnosis/prevention & control; *Hypersensitivity; Allergy; antibiotic; antimicrobial stewardship; delabeling; oral challenge; penicillin
- Department(s)
- Infectious Diseases
- Publisher's Version
- https://doi.org/10.1080/14787210.2023.2296068
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-03-13 05:27:10
Last Modified: 2024-03-13 05:27:28