Perspectives on phenotypic screening-Screen Design and Assay Technology Special Interest Group

Pak, C; Simpson, KJ; Weston, AD; Cvijic, ME; Evans, K; Napper, AD

Author(s): Pak, C; Simpson, KJ; Weston, AD; Cvijic, ME; Evans, K; Napper, AD;
Details: Publication Year 2024-02-02,Volume 29,Issue #2,Page 100146
Journal Title: SLAS Discovery
Publication Type: Online publication before print
Abstract: Here we offer perspectives on phenotypic screening based on a wide-ranging discussion entitled "Phenotypic screening, target ID, and multi-omics: enabling more disease relevance in early discovery?" at the Screen Design and Assay Technology Special Interest Group Meeting at the 2023 SLAS Conference. During the session, the authors shared their own experience from within their respective organizations, followed by an open discussion with the audience. It was recognized that while substantial progress has been made towards translating disease-relevant phenotypic early discovery into clinical success, there remain significant operational and scientific challenges to implementing phenotypic screening efforts, and improving translation of screening hits comes with substantial resource demands and organizational commitment. This Perspective assesses progress, highlights pitfalls, and offers possible solutions to help unlock the therapeutic potential of phenotypic drug discovery. Areas explored comprise screening and hit validation strategy, choice of cellular model, moving beyond 2D cell culture into three dimensions, and leveraging high-dimensional data sets downstream of phenotypic screens.
Department(s): Laboratory Research
Publisher's Version: https://doi.org/10.1016/j.slasd.2024.02.001
Open Access at Publisher's Site: https://doi.org/10.1016/j.slasd.2024.02.001
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-03-13 05:11:31

Last Modified: 2024-03-13 05:25:38