The Potential Contribution of Radiopharmaceutical Therapies in Managing Oligometastatic Disease
- Author(s)
- Kishan, AU; Siva, S; Hofman, MS; Nagarajah, J; Kiess, AP; Tran, P; Calais, J;
- Details
- Publication Year 2024-02-15,Volume 65,Issue #4,Page 502-509
- Journal Title
- Journal of Nuclear Medicine
- Publication Type
- Research article
- Abstract
- There is a growing understanding of the oligometastatic disease state, characterized by the presence of 5 or fewer lesions. Advanced molecular imaging techniques, such as prostate-specific membrane antigen PET, refines the ability to detect oligometastatic recurrences (oligorecurrences) early. These developments have led to the exploration of metastasis-directed therapy (MDT) in oligorecurrent disease as an alternative to or as a means of delaying systemic therapy. Unfortunately, MDT often does not provide a durable cure, and progression-particularly progression in multiple new areas-remains a concern. Simultaneously, developments in radioligand therapy (RLT) have led to studies showing overall survival benefits with α-emitting and β-emitting RLT in advanced, high-volume, metastatic castration-resistant prostate cancer. The success of RLT in late-stage disease suggests that earlier use in the disease spectrum may be impactful. Specifically, integration of RLT with MDT might reduce progression, including polymetastatic progression, in the setting of oligorecurrent disease.
- Publisher
- Society of Nuclear Medicine and Molecular Imaging
- Keywords
- oligometastatic prostate cancer; radioligand therapy; stereotactic body radiotherapy
- Department(s)
- Radiation Oncology; Cancer Imaging
- Publisher's Version
- https://doi.org/10.2967/jnumed.123.266772
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-03-12 06:26:59
Last Modified: 2025-07-17 02:09:23