Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3
- Author(s)
- Thilakasiri, P; O'Keefe, RN; To, SQ; Chisanga, D; Eissmann, MF; Carli, AL; Duscio, B; Baloyan, D; Dmello, RS; Williams, D; Mariadason, J; Poh, AR; Pal, B; Kile, BT; Vissers, JH; Harvey, KF; Buchert, M; Shi, W; Ernst, M; Chand, AL;
- Details
- Publication Year 2024-02,Volume 7,Issue #2,Page e202302411
- Journal Title
- Life Science Alliance
- Publication Type
- Research article
- Abstract
- Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In the context of gastric cancer, YAP1 is a biomarker for poor patient prognosis. Although genomic tumor profiling provides information of Hippo pathway activation, the present study demonstrates that inhibition of Yap1 activity has anti-tumor effects in gastric tumors driven by oncogenic mutations and inflammatory cytokines. We show that Yap1 is a key regulator of cell metabolism, proliferation, and immune responses in normal and neoplastic gastric epithelium. We propose that the Hippo pathway is targetable across gastric cancer subtypes and its therapeutic benefits are likely to be mediated by both cancer cell-intrinsic and -extrinsic mechanisms.
- Publisher
- Life Science Alliance
- Keywords
- Humans; *Stomach Neoplasms/genetics/metabolism/pathology; Tumor Microenvironment; Adaptor Proteins, Signal Transducing/genetics/metabolism; Transcription Factors/genetics/metabolism; Hippo Signaling Pathway; STAT3 Transcription Factor/metabolism
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.26508/lsa.202302411
- Open Access at Publisher's Site
https://doi.org/10.26508/lsa.202302411- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-02-22 12:10:32
Last Modified: 2024-02-22 12:19:10