Confocal microscopy in oral cancer and oral potentially malignant disorders: A systematic review
- Author(s)
- Ramani, RS; Tan, I; Bussau, L; Angel, CM; McCullough, M; Yap, T;
- Details
- Publication Year 2023-11,Volume 29,Issue #8,Page 3003-3015
- Journal Title
- Oral Diseases
- Publication Type
- Review
- Abstract
- OBJECTIVE: To systematically identify and summarise current research on the utility of confocal microscopy in oral squamous cell carcinoma and oral epithelial dysplasia in oral potentially malignant disorders. METHODS: Databases Medline, Embase, Evidence-Based Medicine, and Web of Science were searched with articles screened and included if their primary objective was the use of a confocal microscope in diagnosis of oral cancer or epithelial dysplasia, in vivo or ex vivo. RESULTS AND DISCUSSION: Twenty-eight relevant studies were identified of which 21 studies included oral squamous cell carcinoma specimens. Fifteen studies included in vivo use. The studies included both qualitative and fluorescence confocal microscope and reflectance confocal microscope analysis along with quantitative analysis of carcinoma and dysplasia. Thirteen studies reported the predictive value of their confocal device in the diagnosis of dysplasia and carcinoma. The quantitative software-based studies show promise in objectifying the diagnostic process for identifying abnormalities within the microstructure of the oral mucosa. CONCLUSIONS: There was heterogeneity in the criteria for diagnosis of dysplasia and oral squamous cell carcinoma with experience levels of assessors impacting method efficacy. Both qualitative and quantitative confocal assessment methodologies have been explored, the latter highlighting the potential of future machine-augmented diagnostic precision.
- Publisher
- Wiley
- Keywords
- Humans; *Mouth Neoplasms/diagnostic imaging/pathology; *Carcinoma, Squamous Cell/diagnostic imaging/pathology; Squamous Cell Carcinoma of Head and Neck; *Mouth Diseases/diagnosis; *Precancerous Conditions/pathology; Microscopy, Confocal/methods; *Head and Neck Neoplasms; confocal microscopy; dysplasia; in vivo microscopy; oral cancer
- Department(s)
- Pathology
- PubMed ID
- 35765235
- Publisher's Version
- https://doi.org/10.1111/odi.14291
- Open Access at Publisher's Site
https://doi.org/10.1111/odi.14291- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-02-20 06:52:40
Last Modified: 2024-02-20 07:05:15