A Systematic Review on Prostate-Specific Membrane Antigen Positron Emission Tomography (PSMA PET) Evaluating Localized Low- to Intermediate-Risk Prostate Cancer: A Tool to Improve Risk Stratification for Active Surveillance?

Liu, J; Santucci, J; Woon, DTS; Catterwell, R; Perera, M; Murphy, DG; Lawrentschuk, N

Author(s): Liu, J; Santucci, J; Woon, DTS; Catterwell, R; Perera, M; Murphy, DG; Lawrentschuk, N;
Details: Publication Year 2024-01-02,Volume 14,Issue #1,Page 76
Journal Title: Life
Publication Type: Review
Abstract: Active surveillance remains a treatment option for low- to intermediate-risk prostate cancer (PCa) patients. Prostate-specific membrane antigen positron emission tomography and computed tomography (PSMA PET/CT) has emerged as a useful modality to assess intraprostatic lesions. This systematic review aims to evaluate PSMA PET/CT in localized low- to intermediate-risk PCa to determine its role in active surveillance. Following PRISMA guidelines, a search was performed on Medline, Embase, and Scopus. Only studies evaluating PSMA PET/CT in localized low- to intermediate-risk PCa were included. Studies were excluded if patients received previous treatment, or if they included high-risk PCa. The search yielded 335 articles, of which only four publications were suitable for inclusion. One prospective study demonstrated that PSMA PET/CT-targeted biopsy has superior diagnostic accuracy when compared to mpMRI. One prospective and one retrospective study demonstrated MRI occult lesions in 12.3-29% of patients, of which up to 10% may harbor underlying unfavorable pathology. The last retrospective study demonstrated the ability of PSMA PET/CT to predict the volume of Gleason pattern 4 disease. Early evidence demonstrated the utility of PSMA PET/CT as a tool in making AS safer by detecting MRI occult lesions and patients at risk of upgrading of disease.
Publisher: MDPI
Keywords: active surveillance; prostate cancer; prostate-specific membrane antigen positron emission tomography/computed; tomography
Department(s): Surgical Oncology
Publisher's Version: https://doi.org/10.3390/life14010076
Open Access at Publisher's Site: https://doi.org/10.3390/life14010076
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2024-02-20 12:41:02

Last Modified: 2024-02-20 12:45:33