Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies
- Details
- Publication Year 2023-12,Volume 44,Issue #12,Page 971-985
- Journal Title
- Trends in Immunology
- Publication Type
- Review
- Abstract
- Macrophages represent a key component of the tumor microenvironment (TME) and are largely associated with poor prognosis. Therapeutic targeting of macrophages has historically focused on inhibiting their recruitment or reprogramming their phenotype from a protumor (M2-like) to an antitumor (M1-like) one. Unfortunately, this approach has not provided clinical breakthroughs that have changed practice. Emerging studies utilizing single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics have improved our understanding of the ontogeny, phenotype, and functional plasticity of macrophages. Overlaying the wealth of current information regarding macrophage molecular subtypes and functions has also identified novel therapeutic vulnerabilities that might drive better control of tumor-associated macrophages (TAMs). Here, we discuss the functional profiling of macrophages and provide an update of novel macrophage-targeted therapies in development.
- Keywords
- Humans; *Neoplasms/therapy/pathology; Macrophages/pathology; Phenotype; Tumor Microenvironment; TAM function; macrophage polarization; macrophage-targeted therapy; tumour-associated macrophages
- Department(s)
- Laboratory Research
- Publisher's Version
- https://doi.org/10.1016/j.it.2023.10.007
- Open Access at Publisher's Site
https://doi.org/10.1016/j.it.2023.10.007- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-01-19 06:18:41
Last Modified: 2024-01-19 06:44:07