Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation
Details
Publication Year 2023-12,Volume 53,Issue #12,Page 2162-2174
Journal Title
Internal Medicine Journal
Publication Type
Review
Abstract
Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.
Keywords
Humans; *Posterior Leukoencephalopathy Syndrome/complications; *Hematopoietic Stem Cell Transplantation/adverse effects; *Hematologic Diseases; *Thrombotic Microangiopathies/diagnosis/etiology/therapy; *Pneumonia; endothelial dysfunction; endothelial injury syndrome; haematopoietic stem cell transplant; sinusoidal obstruction syndrome
Department(s)
Clinical Haematology
Open Access at Publisher's Site
https://doi.org/10.1111/imj.16188
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2024-01-19 03:10:21
Last Modified: 2024-01-19 03:11:30

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