Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation
- Author(s)
- McEwan, A; Greenwood, M; Ward, C; Ritchie, D; Szer, J; Gardiner, E; Colic, A; Sipavicius, J; Panek-Hudson, Y; Kerridge, I;
- Details
- Publication Year 2023-12,Volume 53,Issue #12,Page 2162-2174
- Journal Title
- Internal Medicine Journal
- Publication Type
- Review
- Abstract
- Haematopoietic stem cell transplantation is a mainstay of therapy for numerous malignant and nonmalignant diseases. Endothelial activation and dysfunction occur after stem cell transplantation, driven by various patient- and transplant-specific factors. This can manifest as one of the relatively uncommon endothelial injury syndromes, such as sinusoidal obstruction syndrome, transplant-associated thrombotic microangiopathy, idiopathic pneumonia syndrome, capillary leak syndrome, engraftment syndrome or posterior reversible encephalopathy syndrome. This review focuses on the pathogenesis, classification and diagnosis of these disorders, as well as provides guidance on risk mitigation and treatment.
- Keywords
- Humans; *Posterior Leukoencephalopathy Syndrome/complications; *Hematopoietic Stem Cell Transplantation/adverse effects; *Hematologic Diseases; *Thrombotic Microangiopathies/diagnosis/etiology/therapy; *Pneumonia; endothelial dysfunction; endothelial injury syndrome; haematopoietic stem cell transplant; sinusoidal obstruction syndrome
- Department(s)
- Clinical Haematology
- Publisher's Version
- https://doi.org/10.1111/imj.16188
- Open Access at Publisher's Site
https://doi.org/10.1111/imj.16188- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2024-01-19 03:10:21
Last Modified: 2024-01-19 03:11:30