An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
Journal Title
Communications Biology
Publication Type
Research article
Abstract
Despite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide(1). Non-small cell lung cancer (NSCLC) patients have a very poor overall five-year survival rate of only 10-20%. Currently, TNM staging is the gold standard for predicting overall survival and selecting optimal initial treatment options for NSCLC patients, including those with curable stages of disease. However, many patients with locoregionally-confined NSCLC relapse and die despite curative-intent interventions, indicating a need for intensified, individualised therapies. Epithelial-to-mesenchymal transition (EMT), the phenotypic depolarisation of epithelial cells to elongated, mesenchymal cells, is associated with metastatic and treatment-refractive cancer. We demonstrate here that EMT-induced protein changes in small extracellular vesicles are detectable in NSCLC patients and have prognostic significance. Overall, this work describes a novel prognostic biomarker signature that identifies potentially-curable NSCLC patients at risk of developing metastatic NSCLC, thereby enabling implementation of personalised treatment decisions.
Publisher
Springer Nature
Keywords
Humans; *Carcinoma, Non-Small-Cell Lung/drug therapy; *Lung Neoplasms/metabolism; Prognosis; Neoplasm Recurrence, Local; *Extracellular Vesicles/metabolism; Epithelial-Mesenchymal Transition/genetics
Department(s)
Radiation Oncology
PubMed ID
36653467
Open Access at Publisher's Site
https://doi.org/10.1038/s42003-022-04350-4
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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Last Modified: 2023-06-06 06:45:18

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