An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer
- Author(s)
- Lobb, RJ; Visan, KS; Wu, LY; Norris, EL; Hastie, ML; Everitt, S; Yang, IA; Bowman, RV; Siva, S; Larsen, JE; Gorman, JJ; MacManus, M; Leimgruber, A; Fong, KM; Moller, A;
- Journal Title
- Communications Biology
- Publication Type
- Research article
- Abstract
- Despite significant therapeutic advances, lung cancer remains the leading cause of cancer-related death worldwide(1). Non-small cell lung cancer (NSCLC) patients have a very poor overall five-year survival rate of only 10-20%. Currently, TNM staging is the gold standard for predicting overall survival and selecting optimal initial treatment options for NSCLC patients, including those with curable stages of disease. However, many patients with locoregionally-confined NSCLC relapse and die despite curative-intent interventions, indicating a need for intensified, individualised therapies. Epithelial-to-mesenchymal transition (EMT), the phenotypic depolarisation of epithelial cells to elongated, mesenchymal cells, is associated with metastatic and treatment-refractive cancer. We demonstrate here that EMT-induced protein changes in small extracellular vesicles are detectable in NSCLC patients and have prognostic significance. Overall, this work describes a novel prognostic biomarker signature that identifies potentially-curable NSCLC patients at risk of developing metastatic NSCLC, thereby enabling implementation of personalised treatment decisions.
- Publisher
- Springer Nature
- Keywords
- Humans; *Carcinoma, Non-Small-Cell Lung/drug therapy; *Lung Neoplasms/metabolism; Prognosis; Neoplasm Recurrence, Local; *Extracellular Vesicles/metabolism; Epithelial-Mesenchymal Transition/genetics
- Department(s)
- Radiation Oncology
- PubMed ID
- 36653467
- Publisher's Version
- https://doi.org/10.1038/s42003-022-04350-4
- Open Access at Publisher's Site
https://doi.org/10.1038/s42003-022-04350-4- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2023-06-06 06:44:01
Last Modified: 2023-06-06 06:45:18