Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia
Details
Publication Year 2023-11,Volume 4,Issue #4,Page 1105-1109
Journal Title
eJHaem
Publication Type
Research article
Abstract
UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co-mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF-TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF-TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
Keywords
acute leukaemia; cancer genetics; molecular
Department(s)
Clinical Haematology; Pathology; Laboratory Research
Open Access at Publisher's Site
https://doi.org/10.1002/jha2.808
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2023-12-20 12:18:38
Last Modified: 2023-12-20 12:24:05

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