Persistence of UBTF tandem duplications in remission in acute myeloid leukaemia

Author(s): Harrop, S; Nguyen, PC; Byrne, D; Wilson, C; Ryland, GL; Nguyen, T; Anderson, MA; Khaw, SL; Martin, M; Tiong, IS; Sanij, E; Blombery, P;
Details: Publication Year 2023-11,Volume 4,Issue #4,Page 1105-1109
Journal Title: eJHaem
Publication Type: Research article
Abstract: UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co-mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The role of UBTF-TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the UBTF-TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
Keywords: acute leukaemia; cancer genetics; molecular
Department(s): Clinical Haematology; Pathology; Laboratory Research
Publisher's Version: https://doi.org/10.1002/jha2.808
Open Access at Publisher's Site: https://doi.org/10.1002/jha2.808
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2023-12-20 12:18:38

Last Modified: 2023-12-20 12:24:05