An immunomodulating peptide with potential to suppress tumour growth and autoimmunity
Journal Title
Scientific Reports
Publication Type
Research article
Abstract
Cancers and autoimmune diseases commonly co-exist and immune checkpoint inhibitor therapy (ICI) exacerbates autoimmune pathologies. We recently described a lipidic peptide, designated IK14004, that promotes expansion of immunosuppressive T regulatory (Treg) cells and uncouples interleukin-2 from interferon-gamma production while activating CD8+ T cells. Herein, we report IK14004-mediated inhibition of Lewis lung cancer (LLC) growth and re-invigoration of splenocyte-derived exhausted CD4+ T cells. In human immune cells from healthy donors, IK14004 modulates expression of the T cell receptor α/β subunits, induces Type I IFN expression, stimulates natural killer (NK) cells to express NKG2D/NKp44 receptors and enhances K562 cytotoxicity. In both T and NK cells, IK14004 alters the IL-12 receptor β1/β2 chain ratio to favour IL-12p70 binding. Taken together, this novel peptide offers an opportunity to gain further insight into the complexity of ICI immunotherapy so that autoimmune responses may be minimised without promoting tumour evasion from the immune system.
Publisher
Springer Nature
Keywords
Animals; Humans; Autoimmunity; Killer Cells, Natural; T-Lymphocytes, Regulatory; *Autoimmune Diseases/metabolism; *Carcinoma, Lewis Lung/metabolism
Department(s)
Laboratory Research
Open Access at Publisher's Site
https://doi.org/10.1038/s41598-023-47229-y
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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