Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer
Details
Publication Year 2023-10,Volume 41,Issue #4,Page 179-191
Journal Title
Growth Factors
Publication Type
Review
Abstract
Adoption of organoid/tumoroid propagation of normal and malignant intestinal epithelia has provided unparalleled opportunities to compare cell growth factor and signaling dependencies. These 3D structures recapitulate tumours in terms of gene expression regarding the tumor cells but also allow deeper insights into the contribution of the tumour microenvironment (TME). Elements of the TME can be manipulated or added back in the form of infiltrating cytotoxic lymphocytes and/or cancer associated fibroblasts. The effectiveness of chemo-, radio- and immunotherapies can be explored within weeks of deriving these patient-derived tumour avatars informing treatment of these exact patients in a timely manner. Entrenched paths to colorectal cancer (CRC) from the earliest steps of conventional adenoma or serrated lesion formation, and the recognition of further sub-categorisations embodied by consensus-molecular-subtypes (CMS), provide genetic maps allowing a molecular form of pathologic taxonomy. Recent advances in organoid propagation and scRNAseq are reshaping our understanding of CMS and CRC.
Publisher
Taylor & Francis
Keywords
Colorectal cancer; consensus molecular subtypes; organoids; single cell RNAseq
Department(s)
Laboratory Research; Surgical Oncology
PubMed ID
37351905
Terms of Use/Rights Notice
Refer to copyright notice on published article.


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